Short answer:
If you see an opportunity,
yes.
However, keep in mind
it will be even more challenging to get financing
(so bootstrapping often necessary)
and customers are less likely to
take a chance on a brand new product or service
UNLESS they are pretty darn sure
it’ll improve their lives
or there’s some sort of satisfaction guarantee.
As with any business started,
regardless of economic conditions,
expect it to take more time
and more money
than you budget.
Have a buffer for both.